Ontology highlight
ABSTRACT:
SUBMITTER: Covino DA
PROVIDER: S-EPMC6092507 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Covino Daniela A DA Purificato Cristina C Catapano Laura L Galluzzo Clementina M CM Gauzzi Maria Cristina MC Vella Stefano S Lefebvre Eric E Seyedkazemi Star S Andreotti Mauro M Fantuzzi Laura L
Frontiers in immunology 20180808
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family members are cytidine deaminases that play crucial roles in innate responses to retrovirus infection. The mechanisms by which some of these enzymes restrict human immunodeficiency virus type 1 (HIV-1) replication have been extensively investigated <i>in vitro</i>. However, little is known regarding how APOBEC3 proteins affect the pathogenesis of HIV-1 infection <i>in vivo</i> and how antiretroviral therapy influenc ...[more]