Ontology highlight
ABSTRACT:
SUBMITTER: Rust K
PROVIDER: S-EPMC6092623 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rust Katja K Tiwari Manu D MD Mishra Vivek Kumar VK Grawe Ferdi F Wodarz Andreas A
The EMBO journal 20180711 16
Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate differentiating offspring cells. Several chromatin modifiers have been identified as stemness factors in mammalian pluripotent stem cells, but whether these factors control stem cell polarity and asymmetric division has not been investigated so far. We addressed this question in <i>Drosophila</i> neural stem cells called neuroblasts. We identified the Tip60 chromatin remodeling com ...[more]