Ontology highlight
ABSTRACT:
SUBMITTER: Ovalle F
PROVIDER: S-EPMC6092963 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ovalle Fernando F Grimes Tiffany T Xu Guanlan G Patel Anish J AJ Grayson Truman B TB Thielen Lance A LA Li Peng P Shalev Anath A
Nature medicine 20180709 8
Pancreatic beta cell loss is a key factor in the pathogenesis of type 1 diabetes (T1D), but therapies to halt this process are lacking. We previously reported that the approved antihypertensive calcium-channel blocker verapamil, by decreasing the expression of thioredoxin-interacting protein, promotes the survival of insulin-producing beta cells and reverses diabetes in mouse models<sup>1</sup>. To translate these findings into humans, we conducted a randomized double-blind placebo-controlled ph ...[more]