Ontology highlight
ABSTRACT:
SUBMITTER: Singh AK
PROVIDER: S-EPMC6018633 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Singh Appu K AK Saotome Kei K McGoldrick Luke L LL Sobolevsky Alexander I AI
Nature communications 20180625 1
Transient receptor potential (TRP) channels are involved in various physiological processes, including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in epithelia and its expression is dramatically increased in numerous types of cancer. TRPV6 inhibitors suppress tumor growth, but the molecular mechanism of inhibition remains unknown. Here, we present crystal and cryo-EM structures of human and rat TRPV6 bound to 2-aminoethoxydiphenyl borate (2-APB), a TRPV6 inhibitor and mod ...[more]