A mechanism for bistability in glycosylation.
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ABSTRACT:
SUBMITTER: McDonald AG
PROVIDER: S-EPMC6093706 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
A mechanism for bistability in glycosylation.
McDonald Andrew G AG Tipton Keith F KF Davey Gavin P GP
PLoS computational biology 20180803 8
Glycosyltransferases are a class of enzymes that catalyse the posttranslational modification of proteins to produce a large number of glycoconjugate acceptors from a limited number of nucleotide-sugar donors. The products of one glycosyltransferase can be the substrates of several other enzymes, causing a combinatorial explosion in the number of possible glycan products. The kinetic behaviour of systems where multiple acceptor substrates compete for a single enzyme is presented, and the case in ...[more]
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