Ontology highlight
ABSTRACT:
SUBMITTER: Smith Q
PROVIDER: S-EPMC6094121 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Smith Quinton Q Rochman Nash N Carmo Ana Maria AM Vig Dhruv D Chan Xin Yi XY Sun Sean S Gerecht Sharon S
Proceedings of the National Academy of Sciences of the United States of America 20180723 32
Morphogenesis during human development relies on the interplay between physiochemical cues that are mediated in part by cellular density and cytoskeletal tension. Here, we interrogated these factors on vascular lineage specification during human-induced pluripotent stem-cell (hiPSC) fate decision. We found that independent of chemical cues, spatially presented physical cues induce the self-organization of Brachyury-positive mesodermal cells, in a RhoA/Rho-associated kinase (ROCK)-dependent manne ...[more]