Ontology highlight
ABSTRACT:
SUBMITTER: Sebo ZL
PROVIDER: S-EPMC6141776 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Sebo Zachary L ZL Jeffery Elise E Holtrup Brandon B Rodeheffer Matthew S MS
Development (Cambridge, England) 20180817 17
The embryonic origin of distinct fat depots and the role for ontogeny in specifying the functional differences among adipocyte lineages between and within depots is unclear. Using a Cre/Lox-based strategy to track the fate of major mesodermal subcompartments in mice we present evidence that <50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation, ...[more]