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Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor system.

ABSTRACT: Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this "stop-flow" micro-tubing reactor system.

SUBMITTER: Xue F

PROVIDER: S-EPMC6094156 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor system.

Xue Fei F Deng Hongping H Xue Chengwen C Mohamed Dara Khairunnisa Binte DKB Tang Karen Yuanting KY Wu Jie J

Chemical science 20170227 5

Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screenin ...[more]

PMID: 30155207

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