Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor system.

ABSTRACT: Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this "stop-flow" micro-tubing reactor system.

SUBMITTER: Xue F

PROVIDER: S-EPMC6094156 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor system.

Xue Fei F Deng Hongping H Xue Chengwen C Mohamed Dara Khairunnisa Binte DKB Tang Karen Yuanting KY Wu Jie J

Chemical science 20170227 5

Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screenin ...[more]

PMID: 30155207

Similar Datasets

Numerical Simulation of the Gas-Solid Two-Phase Flow-Reaction Process in a Maximizing Isoparaffin Process Reactor.

Project description:The process of the fluid catalytic cracking (FCC) is accompanied by complex physical and chemical reactions and phase transition processes. For the FCC process-maximizing isoparaffin process (MIP), coupled simulation and optimization of flow reaction can meet the requirements for the design and operation of high efficiency, low energy consumption, low pollution, and low cost in the catalytic device. A combination of Eulerian-Eulerian model and 11-lump kinetic model is adopted to simulate the flow-reaction process of gas-solid two-phase of an industrial MIP riser reactor. A drag model based on the energy-minimization multiscale model established by Yang is incorporated into FLUENT through a user-defined function (UDF). The temperature distribution of the catalyst and the concentration of each product component at the outlet are in good agreement with the industrial measured data, which indicates that the established coupling model of flow reaction and drag model are reliable and effective. The two operating variables of the catalyst-to-oil ratio and catalyst inlet temperature are explored their effects on the flow-reaction process of FCC gas-solid two-phase. In the prelifting zone, the velocity of catalyst particles presents parabolic distribution. In the first reaction zone, the maximum velocity of catalyst particles is about 1/2 of the radius of the riser. In the second reaction zone, the maximum particle velocity of catalyst is located in the central region, with a slight increase in about 1/2 of the radius of the riser. The increase in catalyst-to-oil ratio leads to the decrease in the yield of diesel oil and the increase in yields of gasoline, liquefied petroleum gas, propylene, and dry gas. The changes in the catalyst inlet temperature affect the product distribution of the outlet component, which can provide an important guiding significance.

| S-EPMC7857270 | biostudies-literature

The Application of Gas Dwell Time Control for Rapid Single Wall Carbon Nanotube Forest Synthesis to Acetylene Feedstock.

Project description:One aspect of carbon nanotube (CNT) synthesis that remains an obstacle to realize industrial mass production is the growth efficiency. Many approaches have been reported to improve the efficiency, either by lengthening the catalyst lifetime or by increasing the growth rate. We investigated the applicability of dwell time and carbon flux control to optimize yield, growth rate, and catalyst lifetime of water-assisted chemical vapor deposition of single-walled carbon nanotube (SWCNT) forests using acetylene as a carbon feedstock. Our results show that although acetylene is a precursor to CNT synthesis and possesses a high reactivity, the SWCNT forest growth efficiency is highly sensitive to dwell time and carbon flux similar to ethylene. Through a systematic study spanning a wide range of dwell time and carbon flux levels, the relationship of the height, growth rate, and catalyst lifetime is found. Further, for the optimum conditions for 10 min growth, SWCNT forests with ~2500 ?m height, ~350 ?m/min initial growth rates and extended lifetimes could be achieved by increasing the dwell time to ~5 s, demonstrating the generality of dwell time control to highly reactive gases.

| S-EPMC5304639 | biostudies-literature

A Study on the Effect of Flow Unsteadiness on the Yield of a Chemical Reaction in a T Micro-Reactor.

Project description:Despite the very simple geometry and the laminar flow, T-shaped microreactors have been found to be characterized by different and complex steady and unsteady flow regimes, depending on the Reynolds number. In particular, flow unsteadiness modifies strongly the mixing process; however, little is known on how this change may affect the yield of a chemical reaction. In the present work, experiments and 3-dimensional numerical simulations are carried out jointly to analyze mixing and reaction in a T-shaped microreactor with the ultimate goal to investigate how flow unsteadiness affects the reaction yield. The onset of the unsteady asymmetric regime enhances the reaction yield by more than 30%; however, a strong decrease of the yield back to values typical of the vortex regime is observed when the flow undergoes a transition to the unsteady symmetric regime.

| S-EPMC7997225 | biostudies-literature

Synthesis of Micro-/Nanohydroxyapatite Assisted by the Taylor-Couette Flow Reactor.

Project description:Hydroxyapatite (HAP) has received increasing attention as an essential chemical product with good biocompatibility and adsorption properties. Generally, amorphous calcium phosphate (ACP) was generated first in the reactor and transformed into HAP after a period of crystallization. In this work, a series of Taylor-Couette flow reactors with different inner diameters were designed to assist in synthesizing HAP micro-/nanocrystals. ACP was obtained in a Taylor-Couette flow reactor at Re = 247 and successfully transformed into needle-like HAP crystals with a length of about 200 nm and a uniform particle size distribution after crystallization transformation. The yield of a single reactor can reach 2.16 kg per day. The finite element analysis results and time-space diagram of flow pattern variation showed that the Taylor-Couette flow reactor could improve the mixing behavior and the flow field distribution. The Taylor-Couette flow reactor provides a valuable reference for synthesizing inorganic micro-/nanomaterials.

| S-EPMC9730316 | biostudies-literature

A flow reactor setup for photochemistry of biphasic gas/liquid reactions.

Project description:A home-built microreactor system for light-mediated biphasic gas/liquid reactions was assembled from simple commercial components. This paper describes in full detail the nature and function of the required building elements, the assembly of parts, and the tuning and interdependencies of the most important reactor and reaction parameters. Unlike many commercial thin-film and microchannel reactors, the described set-up operates residence times of up to 30 min which cover the typical rates of many organic reactions. The tubular microreactor was successfully applied to the photooxygenation of hydrocarbons (Schenck ene reaction). Major emphasis was laid on the realization of a constant and highly reproducible gas/liquid slug flow and the effective illumination by an appropriate light source. The optimized set of conditions enabled the shortening of reaction times by more than 99% with equal chemoselectivities. The modular home-made flow reactor can serve as a prototype model for the continuous operation of various other reactions at light/liquid/gas interfaces in student, research, and industrial laboratories.

| S-EPMC5082722 | biostudies-literature

Renewable Wood Pulp Paper Reactor with Hierarchical Micro/Nanopores for Continuous-Flow Nanocatalysis.

Project description:Continuous-flow nanocatalysis based on metal nanoparticle catalyst-anchored flow reactors has recently provided an excellent platform for effective chemical manufacturing. However, there has been limited progress in porous structure design and recycling systems for metal nanoparticle-anchored flow reactors to create more efficient and sustainable catalytic processes. In this study, traditional paper is used for a highly efficient, recyclable, and even renewable flow reactor by tailoring the ultrastructures of wood pulp. The "paper reactor" offers hierarchically interconnected micro- and nanoscale pores, which can act as convective-flow and rapid-diffusion channels, respectively, for efficient access of reactants to metal nanoparticle catalysts. In continuous-flow, aqueous, room-temperature catalytic reduction of 4-nitrophenol to 4-aminophenol, a gold nanoparticle (AuNP)-anchored paper reactor with hierarchical micro/nanopores provided higher reaction efficiency than state-of-the-art AuNP-anchored flow reactors. Inspired by traditional paper materials, successful recycling and renewal of AuNP-anchored paper reactors were also demonstrated while high reaction efficiency was maintained.

| S-EPMC5499728 | biostudies-literature

Directional growth of octacalcium phosphate using micro-flow reactor mixing and subsequent aging.

Project description:Well-defined belt-shaped particles of octacalcium phosphate were prepared by mixing aqueous solutions of calcium acetate and that of sodium phosphate monobasic with the aid of a micro-flow reactor. Higher crystallinity and narrower particle size distribution were achieved by the micro-flow reactor if compared with the results of the batch reaction using the same solutions. The width of the belt was controlled by the mixing temperature (0.8 and 2.3 μm for the preparation at 50 and 70 °C, respectively). Post mixing aging at 50 °C, resulted in the directional growth of belt-shaped particles to obtain particles with the length of 17 μm (aspect ratio of 53). XRD and TEM analysis indicated that the micro-flow reactor could separate nucleation and growth allowing preferential growth along the a-direction.

| S-EPMC9031023 | biostudies-literature

Continuous flowing micro-reactor for aqueous reaction at temperature higher than 100 °C.

Project description:Some aqueous reactions in biological or chemical fields are accomplished at a high temperature. When the reaction temperature is higher than 100 °C, an autoclave reactor is usually required to elevate the boiling point of the water by creating a high-pressure environment in a closed system. This work presented an alternative continuous flowing microfluidic solution for aqueous reaction with a reaction temperature higher than 100 °C. The pressure regulating function was successfully fulfilled by a small microchannel based on a delicate hydrodynamic design. Combined with micro heater and temperature sensor that integrated in a single chip by utilizing silicon-based microfabrication techniques, this pressure regulating microchannel generated a high-pressure/high-temperature environment in the upstream reaction zone when the reagents continuously flow through the chip. As a preliminary demonstration, thermal digestion of aqueous total phosphorus sample was achieved in this continuous flowing micro-reactor at a working pressure of 990 kPa (under the working flow rate of 20 nl/s) along with a reaction temperature of 145 °C. This continuous flowing microfluidic solution for high-temperature reaction may find applications in various micro total analysis systems.

| S-EPMC3676394 | biostudies-other

Kinetics Studies on a Multicomponent Knoevenagel-Michael Domino Reaction by an Automated Flow Reactor.

Project description:The optimization of complex chemical reaction systems is often a troublesome and time-consuming process. The application of modern technologies, including automated reactors and analytics, opens the avenue for generating large data sets on chemical reaction processes in a short period of time. In this work, an automated flow reactor is used to present detailed kinetics and mechanistic studies about an amine-catalyzed Knoevenagel-Michael domino reaction to yield tetrahydrochromene derivatives. High-performance monoliths as catalyst supports and online coupled HPLC analysis allow for time-efficient data generation. We show that the two-step multicomponent domino reaction does not follow the kinetics of consecutive reaction steps proceeding independently from each other. Instead, the starting materials of both individual reactions compete for the active sites on the heterogeneous catalyst, which lowers the rate constants of both steps. This knowledge was used to implement a more efficient experimental setup which increased the turnover numbers of the catalyst, without adjusting common reaction parameters like temperature, reaction time, and concentrations.

| S-EPMC6511915 | biostudies-literature

Micro/Nano-pore Network Analysis of Gas Flow in Shale Matrix.

Project description:The gas flow in shale matrix is of great research interests for optimized shale gas extraction. The gas flow in the nano-scale pore may fall in flow regimes such as viscous flow, slip flow and Knudsen diffusion. A 3-dimensional nano-scale pore network model was developed to simulate dynamic gas flow, and to describe the transient properties of flow regimes. The proposed pore network model accounts for the various size distributions and low connectivity of shale pores. The pore size, pore throat size and coordination number obey normal distribution, and the average values can be obtained from shale reservoir data. The gas flow regimes were simulated using an extracted pore network backbone. The numerical results show that apparent permeability is strongly dependent on pore pressure in the reservoir and pore throat size, which is overestimated by low-pressure laboratory tests. With the decrease of reservoir pressure, viscous flow is weakening, then slip flow and Knudsen diffusion are gradually becoming dominant flow regimes. The fingering phenomenon can be predicted by micro/nano-pore network for gas flow, which provides an effective way to capture heterogeneity of shale gas reservoir.

| S-EPMC4642512 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data