Ontology highlight
ABSTRACT:
SUBMITTER: Faghih-Mirzaei E
PROVIDER: S-EPMC6094435 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Faghih-Mirzaei Ehsan E Seifi Mohammad M Abaszadeh Mehdi M Zomorodian Kamiar K Helali Helia H
Iranian journal of pharmaceutical research : IJPR 20180101 3
A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile. The product compounds were tested against bacteria and fungi. It was revealed that compound 5b had th ...[more]