A Neural Circuit Underlying the Generation of Hot Flushes.
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ABSTRACT:
SUBMITTER: Padilla SL
PROVIDER: S-EPMC6094949 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
A Neural Circuit Underlying the Generation of Hot Flushes.
Padilla Stephanie L SL Johnson Christopher W CW Barker Forrest D FD Patterson Michael A MA Palmiter Richard D RD
Cell reports 20180701 2
Hot flushes are a sudden feeling of warmth commonly associated with the decline of gonadal hormones at menopause. Neurons in the arcuate nucleus of the hypothalamus that express kisspeptin and neurokinin B (Kiss1<sup>ARH</sup> neurons) are candidates for mediating hot flushes because they are negatively regulated by sex hormones. We used a combination of genetic and viral technologies in mice to demonstrate that artificial activation of Kiss1<sup>ARH</sup> neurons evokes a heat-dissipation respo ...[more]
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