Ontology highlight
ABSTRACT:
SUBMITTER: Kunrath-Lima M
PROVIDER: S-EPMC6095203 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kunrath-Lima Marianna M de Miranda Marcelo Coutinho MC Ferreira Andrea da Fonseca ADF Faraco Camila Cristina Fraga CCF de Melo Mariane Izabella Abreu MIA Goes Alfredo Miranda AM Rodrigues Michele Angela MA Faria Jerusa Araújo Quintão Arantes JAQA Gomes Dawidson Assis DA
Cellular signalling 20180601
Ca<sup>2+</sup> is an important second messenger, and it is involved in many cellular processes such as cell death and proliferation. The rise in intracellular Ca<sup>2+</sup> levels can be due to the generation of inositol 1,4,5-trisphosphate (InsP<sub>3</sub>), which is a product of phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) hydrolysis by phospholipases C (PLCs), that leads to Ca<sup>2+</sup> release from endoplasmic reticulum by InsP<sub>3</sub> receptors (InsP<sub>3</sub>R). Ca< ...[more]