Ontology highlight
ABSTRACT:
SUBMITTER: Majumder K
PROVIDER: S-EPMC6095691 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Majumder Kinjal K Wang Juexin J Boftsi Maria M Fuller Matthew S MS Rede Jordan E JE Joshi Trupti T Pintel David J DJ
eLife 20180720
We have developed a generally adaptable, novel high-throughput Viral Chromosome Conformation Capture assay (V3C-seq) for use in <i>trans</i> that allows genome-wide identification of the direct interactions of a lytic virus genome with distinct regions of the cellular chromosome. Upon infection, we found that the parvovirus Minute Virus of Mice (MVM) genome initially associated with sites of cellular DNA damage that in mock-infected cells also exhibited DNA damage as cells progressed through S-p ...[more]