Intracellular interleukin-32? mediates antiviral activity of cytokines against hepatitis B virus.
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ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC6095909 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.
Kim Doo Hyun DH Park Eun-Sook ES Lee Ah Ram AR Park Soree S Park Yong Kwang YK Ahn Sung Hyun SH Kang Hong Seok HS Won Ju Hee JH Ha Yea Na YN Jae ByeongJune B Kim Dong-Sik DS Chung Woo-Chang WC Song Moon Jung MJ Kim Kee-Hwan KH Park Seung Hwa SH Kim Soo-Hyun SH Kim Kyun-Hwan KH
Nature communications 20180816 1
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an ...[more]
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