Ontology highlight
ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC6095909 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180816 1
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an ...[more]