Ontology highlight
ABSTRACT:
SUBMITTER: Park SW
PROVIDER: S-EPMC6096353 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Park Sang Won SW Banskota Suhrid S Gurung Pallavi P Jin You Jin YJ Kang Han-Eol HE Chaudhary Chhabi Lal CL Lee Sang Yeul SY Jeong Byeong-Seon BS Kim Jung-Ae JA Nam Tae-Gyu TG
MedChemComm 20180608 8
Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal tract with complex pathogenesis. Here, we synthesized 6-heteroarylamino analogues to inhibit TNF-α-induced adhesion of monocytes to colon epithelial cells which are implicated in the initial inflammation process of IBD. The best analogue, <b>16a</b>, showed IC<sub>50</sub> = 0.29 μM, which is about five orders of magnitude better than that of 5-aminosalicylic acid (5-ASA), a positive control. Oral administration ...[more]