Ontology highlight
ABSTRACT:
SUBMITTER: Haider S
PROVIDER: S-EPMC6479203 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Heliyon 20190422 4
A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound <b>1f</b> exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h respectively. It also exhibited a significant <i>in vitro</i> (p < 0.01), TNF- α inhibitory activity with 51.44 % inhibition. The compound <b>1f</b> showed hydrogen bonding with GLN 61 and interactions with TYR 119, TYR 151 and GLY 121. T ...[more]