Ontology highlight
ABSTRACT:
SUBMITTER: Yamada C
PROVIDER: S-EPMC6096978 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Yamada Chihiro C Mogami Sachiko S Kanno Hitomi H Hattori Tomohisa T
Molecular neurobiology 20180210 9
Apathy is observed across several neurological and psychiatric conditions; however, its pathogenesis remains unclear. We clarified the involvement of brain-gut signaling in the disruption of goal-directed behavior. Male C57BL/6J mice were exposed to water immersion (WI) stress for 3 days. Food intake and nesting behavior were measured as indexes of motivation. Repeated WI caused decrease in food intake and nesting behavior. Plasma levels of peptide YY (PYY), IL-6, and ratio of dopamine metabolit ...[more]