Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC6097020 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Xu Xiaojuan X Wang Senzhen S Chang Yuan Y Ge Chaochao C Li Xinna X Feng Yongli Y Xie Songqiang S Wang Chaojie C Dai Fujun F Luo Wen W
MedChemComm 20180706 8
Naphthalenetetracarboxylic diimide (NDI) is widely used as a photoelectric material in the field of medicine. A series of asymmetric naphthalene diimide derivatives were synthesized and evaluated for their anticancer properties by various experimental assays. As the representative compound, <b>3c</b> exerted significantly greater inhibitory effects on hepatoma cells SMMC-7721 and Hep G2 with an IC<sub>50</sub> value of 1.48 ± 0.43 μM and 1.70 ± 0.53 μM, respectively, than normal hepatocytes QSG- ...[more]