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The Interdialytic Creatinine Rise is a novel marker of volume overload and mortality risk in hemodialysis patients.


ABSTRACT: BACKGROUND:Volume overload poses a major risk in hemodialysis patients but simple detection methods are lacking. We propose a novel marker, the Interdialytic Creatinine Rise (IDCR), readily calculated as the change in serum creatinine over time (in mg/dL/h), to assess volume overload and predict mortality risk in hemodialysis patients. METHODS:First, we calculated IDCR changes with volume in a prospective cohort of 35 hospitalized hemodialysis patients awaiting hemodialysis and 33 hospitalized patients undergoing hemodialysis every other day. Second, in a prospective cohort of 25 outpatients, IDCR cutoff values associated with hypervolemia were determined between two treatments and compared with simultaneous volume assessments by their nephrologist. Third, IDCR as a mortality predictor was studied using survival analysis in a longitudinal retrospective cohort study of 39 maintenance hemodialysis patients followed from 2012 until death or 2017. RESULTS:IDCR decreased by -?0.014 mg/dL/h each day (95%CI -?0.017,-?0.010; p?

SUBMITTER: Ilic LM 

PROVIDER: S-EPMC6097344 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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The Interdialytic Creatinine Rise is a novel marker of volume overload and mortality risk in hemodialysis patients.

Ilic Ljubomir M LM   Davis Roger B RB   Brown Robert S RS   Lecker Stewart H SH  

BMC nephrology 20180816 1


<h4>Background</h4>Volume overload poses a major risk in hemodialysis patients but simple detection methods are lacking. We propose a novel marker, the Interdialytic Creatinine Rise (IDCR), readily calculated as the change in serum creatinine over time (in mg/dL/h), to assess volume overload and predict mortality risk in hemodialysis patients.<h4>Methods</h4>First, we calculated IDCR changes with volume in a prospective cohort of 35 hospitalized hemodialysis patients awaiting hemodialysis and 33  ...[more]

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