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Contribution of volume overload to the arterial stiffness of hemodialysis patients.

ABSTRACT: Arterial stiffness is evaluated with the measurement of pulse wave velocity (PWV), while overhydration (OH) and nutritional status are evaluated with bioimpedance spectroscopy (BIS). In this study, we investigated the effect of a single dialysis session on arterial stiffness, hydration status, and laboratory parameters. The observational, cross-sectional, cohort study included 71?HD patients with mean age 64?±?16?yrs. A Complior device was used to perform PWV measurements. The patients were examined immediately before and 15?min after a mid-week hemodialysis session. Body fluids and nutritional status were studied using a Body Composition Monitor (BCM), Fresenius Medical Care. Clinical and laboratory data were also analyzed. Multivariate regression analysis of PWV before HD showed that an OH increase of 1?L relate to a PWV parameter rise before HD of 0.523?m/s. Multivariate regression analysis of PWV after HD showed that a rise of central SBP after HD of 10?mmHg relate to a PWV increase after HD of 0.707?m/s. Our data indicate that hydration status and blood pressure may be major determinants of PWV in HD patients.

SUBMITTER: Czyzewski L

PROVIDER: S-EPMC6014471 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Contribution of volume overload to the arterial stiffness of hemodialysis patients.

Czyżewski Łukasz Ł Wyzgał Janusz J Czyżewska Emilia E Sierdziński Janusz J Szarpak Łukasz Ł

Renal failure 20171101 1

Arterial stiffness is evaluated with the measurement of pulse wave velocity (PWV), while overhydration (OH) and nutritional status are evaluated with bioimpedance spectroscopy (BIS). In this study, we investigated the effect of a single dialysis session on arterial stiffness, hydration status, and laboratory parameters. The observational, cross-sectional, cohort study included 71 HD patients with mean age 64 ± 16 yrs. A Complior device was used to perform PWV measurements. The patients were exam ...[more]

PMID: 28118756

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Project description:Reduction of cardiovascular death might have a significant effect on the long-term survival rates of renal transplant recipients (RTRs). The aim of the study was to assess the relation between arterial stiffness and graft function, adipose tissue content, and hydration status in patients after kidney transplantation (KTx).The study included 83 RTR patients (mean age: 55?±?13 years) who had been admitted to a nephrology-transplantation outpatient clinic 0.5 to 24 years after KTx. Clinical and laboratory data were analyzed and eGFR was calculated with the CKD-EPI formula. Arterial stiffness was assessed in all RTRs with pulse wave propagation velocity (PWV) with the use of a complior device. In addition, fluid and nutritional status was assessed with a Tanita BC 418 body composition analyzer. The control group consisted of 31 hospital workers who received no medication and had no history of cardiovascular disease.Multivariable linear regression analysis, with PWV as a dependent variable, retained the following independent predictors in the final regression model: red blood cell distribution width (RDW) (B?=?0.323; P?=?0.004), age (B?=?0.297; P?=?0.005), tacrolimus therapy (B?=?-0.286; P?=?0.004), and central DBP (B?=?0.185; P?=?0.041). Multivariable linear regression analysis with eGFR as a dependent variable retained the following independent predictors in the final regression model; creatinine concentration (B?=?-0.632; P?=?0.000), hemoglobin (B?=?0.280; P?=?0.000), CRP (B?=?-0.172; P?=?0.011), tacrolimus therapy (B?=?0.142; P?=?0.039), and triglycerides (B?=?-0.142; P?=?0.035).Our data indicates that: kidney transplant recipients can present modifiable CVD risk factors linked to increased arterial stiffness, DBP, waist circumference, SCr, time on dialysis, CyA therapy, and visceral fat mass; RDW is a parameter associated with arterial stiffness; and parameters such as CyA therapy, time on dialysis, PWV, RDW, and triglycerides show negative associations with the allograft function assessed with eGFR.

Dataset Information

Contribution of volume overload to the arterial stiffness of hemodialysis patients.

Publications

Contribution of volume overload to the arterial stiffness of hemodialysis patients.

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