Complex mechanics of the heterogeneous extracellular matrix in cancer.
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ABSTRACT:
SUBMITTER: Malandrino A
PROVIDER: S-EPMC6097546 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Complex mechanics of the heterogeneous extracellular matrix in cancer.
Malandrino Andrea A Mak Michael M Kamm Roger D RD Moeendarbary Emad E
Extreme Mechanics Letters 20180501
The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix c ...[more]
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