Dataset Information

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging.

ABSTRACT:

Purpose

To develop a 3D adiabatic T_1ρ prepared ultrashort echo time cones (3D AdiabT_1ρ UTE-Cones) sequence for whole knee imaging on a clinical 3T scanner.

Methods

A train of adiabatic full passage pulses were used for spin locking, followed by time-efficient multispoke UTE acquisition to detect signals from both short and long T₂ tissues in the whole knee joint. A modified signal model was proposed for multispoke UTE data fitting. The feasibility of this 3D AdiabT_1ρ UTE-Cones technique was demonstrated through numerical simulation, phantom, and ex vivo knee sample studies. The 3D AdiabT_1ρ UTE-Cones technique was then applied to 6 in vivo knee joints of healthy volunteers to measure T_1ρ values of quadriceps tendon, patellar tendon, anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), meniscus, patellar cartilage, and muscle.

Results

Numerical simulation, phantom and ex vivo knee sample studies demonstrated the feasibility of whole knee imaging using the proposed multispoke 3D AdiabT_1ρ UTE-Cones sequence. The healthy volunteer knee study demonstrated an averaged T_1ρ of 13.9 ± 0.7 ms for the quadriceps tendon, 9.7 ± 0.8 ms for the patellar tendon, 34.9 ± 2.8 ms for the ACL, 21.6 ± 1.4 ms for the PCL, 22.5 ± 1.9 ms for the meniscus, 44.5 ± 2.4 ms for the patellar cartilage, and 43.2 ± 1.1 ms for the muscle.

Conclusion

The 3D AdiabT_1ρ UTE-Cones sequence allows volumetric T_1ρ assessment of both short and long T₂ tissues in the knee joint on a clinical 3T scanner.

SUBMITTER: Ma YJ

PROVIDER: S-EPMC6097905 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

Ma Ya-Jun YJ Carl Michael M Searleman Adam A Lu Xing X Chang Eric Y EY Du Jiang J

Magnetic resonance in medicine 20180228 4

<h4>Purpose</h4>To develop a 3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones (3D AdiabT<sub>1ρ</sub> UTE-Cones) sequence for whole knee imaging on a clinical 3T scanner.<h4>Methods</h4>A train of adiabatic full passage pulses were used for spin locking, followed by time-efficient multispoke UTE acquisition to detect signals from both short and long T<sub>2</sub> tissues in the whole knee joint. A modified signal model was proposed for multispoke UTE data fitting. The feasibility ...[more]

PMID: 29493004

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Project description:BackgroundIn addition to the articular cartilage, osteoarthritis (OA) affects several other tissues such as tendons, ligaments, and subchondral bone. T1ρ relaxation study of these short T2 tissues may provide a more comprehensive evaluation of OA.PurposeTo develop a 3D spin-lattice relaxation in the rotating frame (T1ρ ) prepared zero echo time (ZTE)-based pointwise encoding time reduction with radial acquisition (3D-T1ρ -PETRA) sequence for relaxation mapping of semisolid short-T2 tissues on a clinical 3 T scanner.Study typeProspective.PopulationPhantom, two bovine whole knee joint and Achilles tendon specimens, 10 healthy volunteers with no known inflammation, trauma or pain in the knee or ankle.Field strength/sequenceA customized PETRA sequence to acquire fat-suppressed 3D T1ρ -weighted images tissues with semisolid short T2 / T2* relaxation times in the knee and ankle joints at 3 T.AssessmentMono- and biexponential T1ρ relaxation components were assessed in the patellar tendon (PT), anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), and Achilles tendon (AT).Statistical testsKruskal-Wallis with post-hoc Dunn's test for multiple pairwise comparisons.ResultsPhantom and ex vivo studies showed the feasibility of T1ρ relaxation mapping using the proposed 3D-T1ρ -PETRA sequence. The in vivo study demonstrated an averaged mono-T1ρ relaxation of (median [IQR]) 15.9 [14.5] msec, 23.6 [9.4] msec, 17.4 [7.4] msec, and 5.8 [10.2] msec in the PT, ACL, PCL, and AT, respectively. The bicomponent analysis showed the short and long components (with their relative fractions) of 0.65 [1.0] msec (46.9 [15.3]%) and 37.3 [18.4] msec (53.1 [15.3]%) for PT, 1.7 [2.1] msec (42.5 [12.5]%) and 43.7 [17.8] msec (57.5 [12.5]%) for ACL, and 1.2 [1.9] msec (42.6 [14.0]%) and 27.7 [14.7] msec (57.3 [14.0]%) for PCL and 0.4 [0.02] msec (58.8 [13.3]%/) and 31.3 [10.8] msec (41.2 [13.3]%) for AT. Statistically significant (P ≤ 0.05) differences were observed in the mono- and biexponential relaxation between several regions.Data conclusionThe 3D-T1ρ -PETRA sequence allows volumetric, isotropic (0.78 × 0.78 × 0.78 mm), biexponential T1ρ assessment with corresponding fractions of the tissues with semisolid short T2 / T2* .Level of evidence2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1207-1218.

Dataset Information

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging.

Purpose

Methods

Results

Conclusion

Publications

3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

3D adiabatic T1ρ prepared ultrashort echo time cones sequence for whole knee imaging.

Purpose

Methods

Results

Conclusion

Publications

3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging.