Dataset Information

3D adiabatic T1? prepared ultrashort echo time cones sequence for whole knee imaging.

ABSTRACT: PURPOSE:To develop a 3D adiabatic T1? prepared ultrashort echo time cones (3D AdiabT1? UTE-Cones) sequence for whole knee imaging on a clinical 3T scanner. METHODS:A train of adiabatic full passage pulses were used for spin locking, followed by time-efficient multispoke UTE acquisition to detect signals from both short and long T2 tissues in the whole knee joint. A modified signal model was proposed for multispoke UTE data fitting. The feasibility of this 3D AdiabT1? UTE-Cones technique was demonstrated through numerical simulation, phantom, and ex vivo knee sample studies. The 3D AdiabT1? UTE-Cones technique was then applied to 6 in vivo knee joints of healthy volunteers to measure T1? values of quadriceps tendon, patellar tendon, anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), meniscus, patellar cartilage, and muscle. RESULTS:Numerical simulation, phantom and ex vivo knee sample studies demonstrated the feasibility of whole knee imaging using the proposed multispoke 3D AdiabT1? UTE-Cones sequence. The healthy volunteer knee study demonstrated an averaged T1? of 13.9?±?0.7 ms for the quadriceps tendon, 9.7?±?0.8 ms for the patellar tendon, 34.9?±?2.8 ms for the ACL, 21.6?±?1.4 ms for the PCL, 22.5?±?1.9 ms for the meniscus, 44.5?±?2.4 ms for the patellar cartilage, and 43.2?±?1.1 ms for the muscle. CONCLUSION:The 3D AdiabT1? UTE-Cones sequence allows volumetric T1? assessment of both short and long T2 tissues in the knee joint on a clinical 3T scanner.

SUBMITTER: Ma YJ

PROVIDER: S-EPMC6097905 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

Ma Ya-Jun YJ Carl Michael M Searleman Adam A Lu Xing X Chang Eric Y EY Du Jiang J

Magnetic resonance in medicine 20180228 4

<h4>Purpose</h4>To develop a 3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones (3D AdiabT<sub>1ρ</sub> UTE-Cones) sequence for whole knee imaging on a clinical 3T scanner.<h4>Methods</h4>A train of adiabatic full passage pulses were used for spin locking, followed by time-efficient multispoke UTE acquisition to detect signals from both short and long T<sub>2</sub> tissues in the whole knee joint. A modified signal model was proposed for multispoke UTE data fitting. The feasibility ...[more]

PMID: 29493004

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Project description:BackgroundIn addition to the articular cartilage, osteoarthritis (OA) affects several other tissues such as tendons, ligaments, and subchondral bone. T1ρ relaxation study of these short T2 tissues may provide a more comprehensive evaluation of OA.PurposeTo develop a 3D spin-lattice relaxation in the rotating frame (T1ρ ) prepared zero echo time (ZTE)-based pointwise encoding time reduction with radial acquisition (3D-T1ρ -PETRA) sequence for relaxation mapping of semisolid short-T2 tissues on a clinical 3 T scanner.Study typeProspective.PopulationPhantom, two bovine whole knee joint and Achilles tendon specimens, 10 healthy volunteers with no known inflammation, trauma or pain in the knee or ankle.Field strength/sequenceA customized PETRA sequence to acquire fat-suppressed 3D T1ρ -weighted images tissues with semisolid short T2 / T2* relaxation times in the knee and ankle joints at 3 T.AssessmentMono- and biexponential T1ρ relaxation components were assessed in the patellar tendon (PT), anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), and Achilles tendon (AT).Statistical testsKruskal-Wallis with post-hoc Dunn's test for multiple pairwise comparisons.ResultsPhantom and ex vivo studies showed the feasibility of T1ρ relaxation mapping using the proposed 3D-T1ρ -PETRA sequence. The in vivo study demonstrated an averaged mono-T1ρ relaxation of (median [IQR]) 15.9 [14.5] msec, 23.6 [9.4] msec, 17.4 [7.4] msec, and 5.8 [10.2] msec in the PT, ACL, PCL, and AT, respectively. The bicomponent analysis showed the short and long components (with their relative fractions) of 0.65 [1.0] msec (46.9 [15.3]%) and 37.3 [18.4] msec (53.1 [15.3]%) for PT, 1.7 [2.1] msec (42.5 [12.5]%) and 43.7 [17.8] msec (57.5 [12.5]%) for ACL, and 1.2 [1.9] msec (42.6 [14.0]%) and 27.7 [14.7] msec (57.3 [14.0]%) for PCL and 0.4 [0.02] msec (58.8 [13.3]%/) and 31.3 [10.8] msec (41.2 [13.3]%) for AT. Statistically significant (P ≤ 0.05) differences were observed in the mono- and biexponential relaxation between several regions.Data conclusionThe 3D-T1ρ -PETRA sequence allows volumetric, isotropic (0.78 × 0.78 × 0.78 mm), biexponential T1ρ assessment with corresponding fractions of the tissues with semisolid short T2 / T2* .Level of evidence2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1207-1218.

Dataset Information

3D adiabatic T1? prepared ultrashort echo time cones sequence for whole knee imaging.

Publications

3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

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