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Magic angle effect on adiabatic T_1ρ imaging of the Achilles tendon using 3D ultrashort echo time cones trajectory.

ABSTRACT: The protons in collagen-rich musculoskeletal (MSK) tissues such as the Achilles tendon are subject to strong dipolar interactions which are modulated by the term (3cos² θ-1) where θ is the angle between the fiber orientation and the static magnetic field B₀ . The purpose of this study was to investigate the magic angle effect in three-dimensional ultrashort echo time Cones Adiabatic T_1ρ (3D UTE Cones-AdiabT_1ρ ) imaging of the Achilles tendon using a clinical 3 T scanner. The magic angle effect was investigated by Cones-AdiabT_1ρ imaging of five cadaveric human Achilles tendon samples at five angular orientations ranging from 0° to 90° relative to the B₀ field. Conventional Cones continuous wave T_1ρ (Cones-CW-T_1ρ ) and Cones T₂ * (Cones-T₂ *) sequences were also applied for comparison. On average, Cones-AdiabT_1ρ increased 3.6-fold from 13.6 ± 1.5 ms at 0° to 48.4 ± 5.4 ms at 55°, Cones-CW-T_1ρ increased 6.1-fold from 7.0 ± 1.1 ms at 0° to 42.6 ± 5.2 ms at 55°, and Cones-T2* increased 12.3-fold from 2.9 ± 0.5 ms at 0° to 35.8 ± 6.4 ms at 55°. Although Cones-AdiabT_1ρ is still subject to significant angular dependence, it shows a much-reduced magic angle effect compared to Cones-CW-T_1ρ and Cones-T₂ *, and may be used as a novel and potentially more effective approach for quantitative evaluation of the Achilles tendon and other MSK tissues.

SUBMITTER: Wu M

PROVIDER: S-EPMC7393640 | biostudies-literature |

REPOSITORIES: biostudies-literature

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3D adiabatic T<sub>1ρ</sub> prepared ultrashort echo time cones sequence for whole knee imaging.

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Project description:PURPOSE:To develop an accurate T1 measurement method for short T2 tissues using a combination of a 3-dimensional ultrashort echo time cones actual flip angle imaging technique and a variable repetition time technique (3D UTE-Cones AFI-VTR) on a clinical 3T scanner. METHODS:First, the longitudinal magnetization mapping function of the excitation pulse was obtained with the 3D UTE-Cones AFI method, which provided information about excitation efficiency and B1 inhomogeneity. Then, the derived mapping function was substituted into the VTR fitting to generate accurate T1 maps. Numerical simulation and phantom studies were carried out to compare the AFI-VTR method with a B1 -uncorrected VTR method, a B1 -uncorrected variable flip angle (VFA) method, and a B1 -corrected VFA method. Finally, the 3D UTE-Cones AFI-VTR method was applied to bovine bone samples (N?=?6) and healthy volunteers (N?=?3) to quantify the T1 of cortical bone. RESULTS:Numerical simulation and phantom studies showed that the 3D UTE-Cones AFI-VTR technique provides more accurate measurement of the T1 of short T2 tissues than the B1 -uncorrected VTR and VFA methods or the B1 -corrected VFA method. The proposed 3D UTE-Cones AFI-VTR method showed a mean T1 of 240?±?25 ms for bovine cortical bone and 218?±?10 ms for the tibial midshaft of human volunteers, respectively, at 3?T. CONCLUSION:The 3D UTE-Cones AFI-VTR method can provide accurate T1 measurements of short T2 tissues such as cortical bone. Magn Reson Med 80:598-608, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

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