Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers.
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ABSTRACT:
SUBMITTER: Nambiar M
PROVIDER: S-EPMC6097939 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers.
Nambiar Mridula M Smith Gerald R GR
Molecular cell 20180802 4
In most eukaryotes, meiotic crossovers are essential for error-free chromosome segregation but are specifically repressed near centromeres to prevent missegregation. Recognized for >85 years, the molecular mechanism of this repression has remained unknown. Meiotic chromosomes contain two distinct cohesin complexes: pericentric complex (for segregation) and chromosomal arm complex (for crossing over). We show that the pericentric-specific complex also actively represses pericentric meiotic double ...[more]
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