Estimation of lifetime risks of Alzheimer's disease dementia using biomarkers for preclinical disease.
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ABSTRACT:
SUBMITTER: Brookmeyer R
PROVIDER: S-EPMC6097953 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Estimation of lifetime risks of Alzheimer's disease dementia using biomarkers for preclinical disease.
Brookmeyer Ron R Abdalla Nada N
Alzheimer's & dementia : the journal of the Alzheimer's Association 20180522 8
<h4>Introduction</h4>Lifetime risks are the probabilities of progressing to Alzheimer's disease (AD) dementia during one's lifespan. Here, we report the first estimates of the lifetime and ten-year risks of AD dementia based on age, gender, and biomarker tests for preclinical disease.<h4>Methods</h4>We used a multistate model for the disease process together with US death rates.<h4>Results</h4>Lifetime risks of AD dementia vary considerably by age, gender, and the preclinical or clinical disease ...[more]
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