Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia.

ABSTRACT: To characterize the course of Alzheimer's disease (AD) over a longer time interval, we aimed to construct a disease course model for the entire span of the disease using two separate cohorts ranging from preclinical AD to AD dementia. We modelled the progression course of 436 patients with AD continuum and investigated the effects of apolipoprotein E ?4 (APOE ?4) and sex on disease progression. To develop a model of progression from preclinical AD to AD dementia, we estimated Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 (ADAS-cog 13) scores. When calculated as the median of ADAS-cog 13 scores for each cohort, the estimated time from preclinical AD to MCI due to AD was 7.8 years and preclinical AD to AD dementia was 15.2 years. ADAS-cog 13 scores deteriorated most rapidly in women APOE ?4 carriers and most slowly in men APOE ?4 non-carriers (p?

SUBMITTER: Cho SH 

PROVIDER: S-EPMC7893024 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature