Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank.
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ABSTRACT:
SUBMITTER: Loftfield E
PROVIDER: S-EPMC6098142 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank.
Loftfield Erikka E Zhou Weiyin W Graubard Barry I BI Yeager Meredith M Chanock Stephen J SJ Freedman Neal D ND Machiela Mitchell J MJ
Scientific reports 20180817 1
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural somatic event. Previous studies have indicated age and cigarette smoking increase the risk of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not been adequately investigated. We characterized mLOY in a large cohort of 223,338 men from the UK Biobank by scanning for deviations in genotyping array median log<sub>2</sub> intensity ratios (mLRR) of the Y chromosome using a standar ...[more]
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