Ontology highlight
ABSTRACT:
SUBMITTER: Jha RM
PROVIDER: S-EPMC6098411 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Journal of neurotrauma 20180606 17
Cerebral edema is critical to morbidity/mortality in traumatic brain injury (TBI) and is worsened by hypotension. Glibenclamide may reduce cerebral edema by inhibiting sulfonylurea receptor-1 (Sur1); its effect on diffuse cerebral edema exacerbated by hypotension/resuscitation is unknown. We aimed to determine if glibenclamide improves pericontusional and/or diffuse edema in controlled cortical impact (CCI) (5m/sec, 1 mm depth) plus hemorrhagic shock (HS) (35 min), and compare its effects in CCI ...[more]