Ontology highlight
ABSTRACT:
SUBMITTER: Mayer AR
PROVIDER: S-EPMC7307133 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Mayer Andrew R AR Dodd Andrew B AB Vermillion Meghan S MS Stephenson David D DD Chaudry Irshad H IH Bragin Denis E DE Gigliotti Andrew P AP Dodd Rebecca J RJ Wasserott Benjamin C BC Shukla Priyank P Kinsler Rachel R Alonzo Sheila M SM
Neuroscience and biobehavioral reviews 20190627
Traumatic brain injury (TBI) and severe blood loss (SBL) frequently co-occur in human trauma, resulting in high levels of mortality and morbidity. Importantly, each of the individual post-injury cascades is characterized by complex and potentially opposing pathophysiological responses, complicating optimal resuscitation and therapeutic approaches. Large animal models of poly-neurotrauma closely mimic human physiology, but a systematic literature review of published models has been lacking. The c ...[more]