Ontology highlight
ABSTRACT:
SUBMITTER: Kerr NA
PROVIDER: S-EPMC6098413 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kerr Nadine A NA de Rivero Vaccari Juan Pablo JP Abbassi Sam S Kaur Harmanpreet H Zambrano Ronald R Wu Shu S Dietrich W Dalton WD Keane Robert W RW
Journal of neurotrauma 20180608 17
Approximately 20-25% of traumatic brain injury (TBI) subjects develop acute lung injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Our previous work has shown that the inflammasome plays a critical role in TBI-induced secondary pathophysiology and that inflammasome proteins are released in extracellular vesicles (EV) after TBI. Here we investigated whether EV-mediated inflammasome signaling contributed to the etiology of TBI-induced ALI. C57/BL6 male mice were subje ...[more]