The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis.

ABSTRACT: BACKGROUND:The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH). METHODS:The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Internet (CNKI) until May, 2017. In addition, odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as a measure of effect size for calculating effect size. RESULTS:Totally, six case-control studies were included in this meta-analysis. It revealed that ApoB-C7623T polymorphism frequency was increased in ONFH group than in control group under three genetic models, including allele model (T vs. C, OR?=?4.5149, 95% CI: 1.6968-12.0134); additive model (TC vs. CC, OR?=?6.2515, 95% CI: 2.0939-18.6640); and dominant model (TT?+?TC vs. CC, OR?=?5.4998, 95% CI: 1.9246-15.7163). In addition, the increased risk of ONFH were related to ApoA1-rs1799837 polymorphism under additive model (AA vs. GG, OR?=?1.4175, 95% CI: 1.0522-1.9096) and recessive model (AA vs. GG?+?AG, OR?=?1.7727, 95% CI: 1.3399-2.3452). However, four ApoB rs1042031, rs693, 3'-VNTR and G12619A polymorphisms under the all genetic models were not associated with susceptibility to ONFH. CONCLUSION:The T allele and TC genotype of ApoB-C7623T and AA genotype of ApoA1-rs1799837 may contribute to increase the risk of ONFH.

SUBMITTER: Hao Y 

PROVIDER: S-EPMC6098662 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature