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Synthetic efforts towards the stereoselective synthesis of NF00659B1.

ABSTRACT: NF00659B1 is a novel ?-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.

SUBMITTER: Kwon DY

PROVIDER: S-EPMC6098985 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Synthetic efforts towards the stereoselective synthesis of NF00659B1.

Kwon Do-Yeon DY Lee Kiyoun K Park Hyeri H Kim Mi Jung MJ Hong Jiyong J

Bioorganic & medicinal chemistry letters 20180219 16

NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies. ...[more]

PMID: 29503022

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