Ontology highlight
ABSTRACT:
SUBMITTER: Kwon DY
PROVIDER: S-EPMC6098985 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kwon Do-Yeon DY Lee Kiyoun K Park Hyeri H Kim Mi Jung MJ Hong Jiyong J
Bioorganic & medicinal chemistry letters 20180219 16
NF00659B<sub>1</sub> is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B<sub>1</sub> is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B<sub>1</sub> for further biological studies. ...[more]