Ontology highlight
ABSTRACT:
SUBMITTER: Pirola M
PROVIDER: S-EPMC6631789 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190618 12
A stereoselective synthetic strategy for the preparation of trifluoromethylamine mimics of retro-thiorphan, involving a diastereoselective, metal-free catalytic step, has been studied in batch and afforded the target molecule in good yields and high diastereoselectivity. A crucial point of the synthetic sequence was the catalytic reduction of a fluorinated enamine with trichlorosilane as reducing agent in the presence of a chiral Lewis base. The absolute configuration of the key intermediate was ...[more]