Hansenula polymorpha Aat2p is targeted to peroxisomes via a novel Pex20p-dependent pathway.
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ABSTRACT:
SUBMITTER: Thomas AS
PROVIDER: S-EPMC6099311 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Hansenula polymorpha Aat2p is targeted to peroxisomes via a novel Pex20p-dependent pathway.
Thomas Ann S AS Krikken Arjen M AM de Boer Rinse R Williams Chris C
FEBS letters 20180630 14
Saccharomyces cerevisiae Aat2p contains a peroxisomal targeting signal type-1 and localizes to peroxisomes in oleate-grown cells, but not in glucose-grown cells. Here, we have investigated Aat2p from the yeast Hansenula polymorpha, which lacks a recognizable peroxisomal targeting signal. Aat2p tagged with GFP at its C terminus displays a dual cytosol-peroxisome localization in ethanol-grown cells. The partial peroxisomal localization of Aat2p persisted in the absence of the classical cycling rec ...[more]
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