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Interleukin-33: Its Emerging Role in Allergic Diseases.

ABSTRACT: Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the quality of life of people all over the world. Recently, interleukin-33 (IL-33) has been found to play an important role in these refractory disorders, mainly by inducing T helper (Th) 2 immune responses. This article reviews the mobilization and biological function of IL-33 in allergic disorders, providing novel insights for addressing these hypersensitive conditions.

SUBMITTER: Ding W

PROVIDER: S-EPMC6099536 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Interleukin-33: Its Emerging Role in Allergic Diseases.

Ding Wen W Zou Gui-Lin GL Zhang Wei W Lai Xing-Ning XN Chen Hou-Wen HW Xiong Li-Xia LX

Molecules (Basel, Switzerland) 20180709 7

Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the quality of life of people all over the world. Recently, interleukin-33 (IL-33) has been found to play an important role in these refractory disorders, mainly by inducing T helper (Th) 2 immune responses. This article reviews the mobilization and biological function of IL-33 in allergic disorders, providing no ...[more]

PMID: 29987222

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