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Interleukin-33 and inflammatory bowel diseases: lessons from human studies.

ABSTRACT: Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.

SUBMITTER: Nunes T

PROVIDER: S-EPMC3950548 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Interleukin-33 and inflammatory bowel diseases: lessons from human studies.

Nunes Tiago T Bernardazzi Claudio C de Souza Heitor S HS

Mediators of inflammation 20140220

Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damag ...[more]

PMID: 24701033

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