Ontology highlight
ABSTRACT:
SUBMITTER: Ballone A
PROVIDER: S-EPMC6099619 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20180608 6
In recent years, targeting the complex network of protein⁻protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hund ...[more]