Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches.

ABSTRACT: Activating Liver X receptors (LXRs) represents a promising therapeutic option for dyslipidemia. However, activating LXRα may cause undesired lipogenic effects. Discovery of highly LXRβ-selective agonists without LXRα activation were indispensable for dyslipidemia. In this study, in silico approaches were applied to develop highly potent LXRβ-selective agonists based on a series of newly reported 3-(4-(2-propylphenoxy)butyl)imidazolidine-2,4-dione-based LXRα/β dual agonists. Initially, Kohonen and stepwise multiple linear regression SW-MLR were performed to construct models for LXRβ agonists and LXRα agonists based on the structural characteristics of LXRα/β dual agonists, respectively. The obtained LXRβ agonist model gave a good predictive ability (R²_train = 0.837, R²_test</

SUBMITTER: Chen M 

PROVIDER: S-EPMC6099648 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature