Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6099740 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Liu Xiaobo X Kou Jianlan J Xiao Zhen Z Tian Fajuan F Hu Jiayi J Zheng Pengwu P Zhu Wufu W
Molecules (Basel, Switzerland) 20180626 7
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, a series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing pyridazinone derivatives were designed, synthesized and evaluated for their enzymatic inhibitory activity against c-Met kinase and cellular potency against A549, HepG2, and MCF-7 cell lines. Eight of them are equal to more ...[more]