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C19-Norditerpenoid Alkaloids from Aconitum szechenyianum.

ABSTRACT: Three new C₁₉-norditerpenoid alkaloids (1?3), along with two known C₁₉-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppressive effects of compounds 1?5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC₅₀/IC₅₀ values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.

SUBMITTER: Song B

PROVIDER: S-EPMC6100137 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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C19-Norditerpenoid Alkaloids from Aconitum szechenyianum.

Song Bei B Jin Bingliang B Li Yuze Y Wang Fei F Yang Yifu Y Cui Yuwen Y Song Xiaomei X Yue Zhenggang Z Liu Jianli J

Molecules (Basel, Switzerland) 20180508 5

Three new C19-norditerpenoid alkaloids (1⁻3), along with two known C19-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppr ...[more]

PMID: 29738430

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