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Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis.

ABSTRACT: Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively.

SUBMITTER: Guo DL

PROVIDER: S-EPMC6100219 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis.

Guo Da-Le DL Li Xiao-Hua XH Feng Dan D Jin Meng-Ying MY Cao Yu-Mei YM Cao Zhi-Xing ZX Gu Yu-Cheng YC Geng Zhao Z Deng Fang F Deng Yun Y

Molecules (Basel, Switzerland) 20180713 7

Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity ag ...[more]

PMID: 30011828

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