Ontology highlight
ABSTRACT:
SUBMITTER: Purgatorio R
PROVIDER: S-EPMC6100259 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Purgatorio Rosa R de Candia Modesto M De Palma Annalisa A De Santis Francesco F Pisani Leonardo L Campagna Francesco F Cellamare Saverio S Altomare Cosimo Damiano CD Catto Marco M
Molecules (Basel, Switzerland) 20180626 7
Despite the controversial outcomes of clinical trials executed so far, the prevention of β-amyloid (Aβ) deposition and neurotoxicity by small molecule inhibitors of Aβ aggregation remains a target intensively pursued in the search of effective drugs for treating Alzheimer’s disease (AD) and related neurodegeneration syndromes. As a continuation of previous studies, a series of new 3-(2-arylhydrazono)indolin-2-one derivatives was synthesized and assayed, investigating the effects of substitutions ...[more]