RRY Inhibits Amyloid-β_1-42 Peptide Aggregation and Neurotoxicity.

ABSTRACT:

Background

Current understanding of amyloid-β protein (Aβ) aggregation and toxicity provides an extensive list of drugs for treating Alzheimer's disease (AD); however, one of the most promising strategies for its treatment has been tri-peptides.

Objective

The aim of this study is to examine those tri-peptides, such as Arg-Arg-Try (RRY), which have the potential of Aβ_1-42 aggregating inhibition and Aβ clearance.

Methods

In the present study, in silico, in vitro, and in vivo studies were integrated for screening tri-peptides binding to Aβ, then evaluating its inhibition of aggregation of Aβ, and finally its rescuing cognitive deficit.

Results

In the in silico simulations, molecular docking and molecular dynamics determined t

SUBMITTER: Sun X 

PROVIDER: S-EPMC8293670 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature