Ontology highlight
ABSTRACT:
SUBMITTER: Colgan LA
PROVIDER: S-EPMC6100743 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Colgan Lesley A LA Hu Mo M Misler Jaime A JA Parra-Bueno Paula P Moran Corey M CM Leitges Michael M Yasuda Ryohei R
Nature neuroscience 20180716 8
The protein kinase C (PKC) enzymes have long been established as critical for synaptic plasticity. However, it is unknown whether Ca<sup>2+</sup>-dependent PKC isozymes are activated in dendritic spines during plasticity and, if so, how this synaptic activity is encoded by PKC. Here, using newly developed, isozyme-specific sensors, we demonstrate that classical isozymes are activated to varying degrees and with distinct kinetics. PKCα is activated robustly and rapidly in stimulated spines and is ...[more]