Ontology highlight
ABSTRACT:
SUBMITTER: Ashley SE
PROVIDER: S-EPMC6101967 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Ashley Sarah E SE Meyer Braydon A BA Ellis Justine A JA Martino David J DJ
Journal of visualized experiments : JoVE 20180621 136
Complex diseases are often underpinned by multiple common genetic variants that contribute to disease susceptibility. Here, we describe a cost-effective tag single nucleotide polymorphism (SNP) approach using a multiplexed genotyping assay with mass spectrometry, to investigate gene pathway associations in clinical cohorts. We investigate the food allergy candidate locus Interleukin13 (IL13) as an example. This method efficiently maximizes the coverage by taking advantage of shared linkage diseq ...[more]