Ontology highlight
ABSTRACT:
SUBMITTER: Goode BL
PROVIDER: S-EPMC6102064 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Goode Bruce L BL Sweeney Meredith O MO Eskin Julian A JA
Trends in cell biology 20180518 9
Glia maturation factor (GMF) has recently been established as a regulator of the actin cytoskeleton with a unique role in remodeling actin network architecture. Conserved from yeast to mammals, GMF is one of five members of the ADF-H family of actin regulatory proteins, which includes ADF/cofilin, Abp1/Drebrin, Twinfilin, and Coactosin. GMF does not bind actin, but instead binds the Arp2/3 complex with high affinity. Through this association, GMF catalyzes the debranching of actin filament netwo ...[more]