Ontology highlight
ABSTRACT:
SUBMITTER: Sieker JT
PROVIDER: S-EPMC6102098 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20180220
To determine the transcriptional profile of synovium during the molecular phase of post-traumatic osteoarthritis, anterior cruciate ligament transections (ACL) were performed in 36 Yucatan minipigs. Equal numbers were randomly assigned to no further treatment, ACL reconstruction or repair. Perimeniscal synovium for histopathology and RNA-sequencing was harvested at 1 and 4 weeks post-operatively and from six healthy control animals. Microscopic synovitis scores significantly worsened at 1 (p < 0 ...[more]