Ontology highlight
ABSTRACT:
SUBMITTER: Lazarus KA
PROVIDER: S-EPMC6102279 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180820 1
Patients diagnosed with lung squamous cell carcinoma (LUSC) have limited targeted therapies. We report here the identification and characterisation of BCL11A, as a LUSC oncogene. Analysis of cancer genomics datasets revealed BCL11A to be upregulated in LUSC but not in lung adenocarcinoma (LUAD). Experimentally we demonstrate that non-physiological levels of BCL11A in vitro and in vivo promote squamous-like phenotypes, while its knockdown abolishes xenograft tumour formation. At the molecular lev ...[more]