Ontology highlight
ABSTRACT:
SUBMITTER: Liu CC
PROVIDER: S-EPMC6104168 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Liu Chan-Chuan CC Ho Pei-Chuan PC Lee I-Ting IT Chen Yu-An YA Chu Chun-Hsien CH Teng Chih-Chuan CC Wu Sheng-Nan SN Sze Chun-I CI Chiang Ming-Fu MF Chang Nan-Shan NS
Frontiers in neuroscience 20180815
Homozygous null mutation of tumor suppressor <i>WWOX/Wwox</i> gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats. WWOX is frequently downregulated in the hippocampi of patients with Alzheimer's disease (AD). <i>In vitro</i> analysis revealed that knockdown of WWOX protein in neuroblastoma cells results in aggregation of TRAPPC6AΔ, TIAF1, amyloid β, and Tau in a sequential manner. Indeed, TRAPPC6AΔ and TIAF1, but not tau and amyloid ...[more]