Genetics of Severe Obesity.
Ontology highlight
ABSTRACT:
SUBMITTER: Fairbrother U
PROVIDER: S-EPMC6105241 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Genetics of Severe Obesity.
Fairbrother Una U Kidd Elliot E Malagamuwa Tanya T Walley Andrew A
Current diabetes reports 20180818 10
<h4>Purpose of review</h4>This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R.<h4>Recent findings</h4>There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants ...[more]
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