Unknown

Dataset Information

0

Genetics of Obesity in Diverse Populations.


ABSTRACT: PURPOSE OF REVIEW:The prevalence of obesity continues to rise, fueling a global public health crisis characterized by dramatic increases in type 2 diabetes, cardiovascular disease, and many cancers. In the USA, several minority populations, who bear much of the obesity burden (47% in African Americans and Hispanic/Latinos, compared to 38% in European descent groups), are particularly at risk of downstream chronic disease. Compounding these disparities, most genome-wide association studies (GWAS)-including those of obesity-have largely been conducted in populations of European or East Asian ancestry. In fact, analysis of the GWAS Catalog found that while the proportion of participants of non-European or non-Asian descent had risen from 4% in 2009 to 19% in 2016, African-ancestry participants are still just 3% of GWAS, Hispanic/Latinos are

SUBMITTER: Young KL 

PROVIDER: S-EPMC6380516 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genetics of Obesity in Diverse Populations.

Young Kristin L KL   Graff Mariaelisa M   Fernandez-Rhodes Lindsay L   North Kari E KE  

Current diabetes reports 20181119 12


<h4>Purpose of review</h4>The prevalence of obesity continues to rise, fueling a global public health crisis characterized by dramatic increases in type 2 diabetes, cardiovascular disease, and many cancers. In the USA, several minority populations, who bear much of the obesity burden (47% in African Americans and Hispanic/Latinos, compared to 38% in European descent groups), are particularly at risk of downstream chronic disease. Compounding these disparities, most genome-wide association studie  ...[more]

Similar Datasets

| S-EPMC3706771 | biostudies-literature
| 2160185 | ecrin-mdr-crc
| S-EPMC3685296 | biostudies-literature
| S-EPMC4278349 | biostudies-literature
| S-EPMC4992482 | biostudies-literature
| S-EPMC3136227 | biostudies-literature
| S-EPMC2955913 | biostudies-literature
| S-EPMC6105241 | biostudies-literature
| S-EPMC8346377 | biostudies-literature
| S-EPMC4673034 | biostudies-literature